Last
modified
June 4, 2009
|
|
 ::
TRANSGENIC RABBITS AS HUMAN DISEASE MODELS ::
|
|
Rabbit
strains have a more diverse genetic
background than inbred and outbred mouse strains.
This might be an advantage when studying complex disease models
such as atherosclerosis or developing therapeutic strategies,
since this situation mimics human genetic diversity more accurately.
Though transgenic mice have become the most widely used model
for human diseases, it is accepted in certain cases that the
causative mutations resulting in human diseases do not give
rise to the expected pathological symptoms in rodents.
Rabbit
has demonstrated interest in the study of some diseases:
-
Lipid metabolism and atherosclerosis
- Hypertrophic cardiomyopathy
- Susceptibility to tuberculosis
- Cystic Fibrosis
- AIDS, cancer and spongiform encephalopathy studies
- Anatomical and metabolic disorders
- Use of GFP rabbits
-->
More...
|
| Up
to recent times,
transgenic rabbit as animal models were poorly developed
in comparison to mice and rats due to the lack of genetic
engineering tools available in rabbits. With the improvement
of techniques (gene knock-down, gene knock-out, or gene
replacement) and development of methods applicable to
rabbits, BioProtein Transgenics is currently in position
to propose fully integrated
services for transgenic rabbit generation. |
|
|
::
TRANSGENIC RABBITS AS BIOREACTORS ::
|
For more information about this activity, please visit BioProtein
Technologies' website.
--> More...
|
|
