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COMPANY ::::: |
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MISSION ::
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| BioProtein
Technologies is the world leader in the production
of recombinant therapeutic proteins
& vaccines in the milk of transgenic rabbits.
BioProtein
Technologies is a Contract Manufacturing
Organization (CMO). The Company provides pharmaceutical
and biotechnology companies with a fully integrated service
from gene expression to industrial production of proteins
and vaccines in milk.
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proprietary technology offers customized packages supplying
gram to kilogram
quantities of highly purified biopharmaceuticals
with competitive advantages in terms of scale-up and time
to market.
A strong expertise through the entire manufacturing process
particularly in molecular and cellular biology, embryology,
dairy science, and animal housing, allows the Company to successfully
produce complex glycosylated
proteins or vaccines
in the milk of transgenic rabbits (e.g. monoclonal
antibodies, plasma proteins, hormones, peptides and VLP-based
multivalent vaccines.) -->
More...
BioProtein
Technologies has demonstrated its ability to meet the most
rigorous specifications in protein production and purification
through recombinant proteins production programs, carried
out in collaboration with several biotechnology companies.
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:: HISTORY ::
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BioProtein
Technologies was founded by three scientists involved in transgenic
animal and cloning research, Louis-Marie Houdebine, Jean-Paul
Renard and Bernard Jégou, and an experienced manager
from the business consultancy world, Marc Le Bozec. They shared
the same view on the potential industrial applications of nearly
15 years of cutting-edge research in the field of gene expression
and transgenic technology.
This view was soon backed by the top management of INRA, which
provided the original core technology. ”BioProtein Technologies”
was thus founded as a spin-off of INRA on July 1st 1998.
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In
2001, the Company successfully closed a € 5 M round of
financing with international investors providing the Company
with a solid visibility and stability to implement its plans.
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::::::::::::THE
FOUNDERS
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Marc
Le Bozec //graduated from HEC//
He acquired proficiency in business management and in management
of innovation especially within prestigious practices (Bossard
Consultants – Gemini Consulting – and Arthur D. Little). |
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Louis-Marie
Houdebine //Ph.D, Chemical engineer//
He is director of the Animal Gene Study Laboratory at INRA (French
National Agronomy Research Institute - Jouy-en-Josas, Yvelines
– France). He is recognized worldwide as one of the leading
specialists in the production of recombinant proteins in the
milk of transgenic animals. He developed a pole of expertise
in the field of vectors carrying genes. |
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Jean-Paul
Renard //Ph.D.,
engineer in agronomy//
He is director of the Developmental Biology and Biotechnology
Unit at INRA (Jouy-en-Josas, Yvelines – France).
He is internationally recognized as one of the best specialists
in the field of domestic animal cloning, particularly for pharmaceutical
applications. |
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Bernard
Jégou //Ph.D.//
He is director of the Animal Research Group for Male Reproduction
at INSERM (French National Institute for Medical Research -Rennes
University – France).
He is carrying out ambitious projects in the field of spermatogenesis. |
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François
Deneux //graduated from ESSEC//
He is currently responsible for the healthcare practice
of Arthur D. Little in France.
He has more than 12 years experience in strategy and management
consulting especially within prestigious practices (Bossard
Consultants – Gemini Consulting – and Arthur D. Little).
He has been Managing Director of BioProtein Technologies from
its creation in July 1998 up to May 2000. |
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:: COLLABORATIONS ::
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:: INDUSTRIAL PARTNERSHIP ::
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BioProtein
Technologies has concluded manufacturing agreements with LFB (French
Laboratory for Plasma Fractionation and Biotechnology) for feasibility
studies regarding the production of recombinant proteins in the
milk of transgenic rabbits.
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:: RESEARCH PARTNERSHIPS ::
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BioProtein
Technologies has a privileged partnership
with INRA (the French National Institute for Agronomic
Research).
INRA is one the most important research institutes in France;
with a budget of € 520 M, 10.000 employees and a number
of patents and breeders rights covering 500 marketed commercial
crops. |
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partnership provides BioProtein Technologies with: |
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Know-how
transfer, particularly in the fields of molecular biology, developmental
biology and animal production. |
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Exclusive
access to intellectual property: an exclusive licence for the
production of proteins in milk. |
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Logistics
support, laboratory and staff resources. |
BioProtein
Technologies has concluded agreements with top league laboratories
or public research organizations:
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INRA
Laboratory of Cellular and Molecular Biology (LM. Houdebine)
Laboratory of Biology of Development (JP. Renard)
Laboratory of the Study of Gonadotropins (F. Guillou)
Laboratory of Molecular Virology and Immunology (J. Cohen)
USTL
(Université
des Sciences et Technologies de Lille)
Laboratory of Structural and Functionnal Glycobiology (JC.
Michalsky)
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:: RESOURCES :: |
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| HEADQUARTES
(LYON) |
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| OFFICES |
Headquarters
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| JOUY-EN-JOSAS
SITE (PARIS): RESEARCH & DEVELOPMENT |
| SALES
GENERAL & ADMINISTRATIVE |
The
team is composed of 3 persons includin 1 Chief Finance
Officer, 1 Business Development Director, 1 secretary |
| MOLECULAR
BIOLOGY |
150
m² Laboratory: Research
and development, The molecular biology team is made
of 2 PhDs and 1 technician. |
EMBRYOLOGY
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200
m2 Laboratory: in charge of micro-injection
and embryo transfert manipulations. The team is
made up of 3 scientists of which 1 is a Ph.D. |
| PILOT
HUSBANDRY |
200
Rabbits Husbandry |
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| MAGNERAUD
SITE (WEST FRANCE): HUSNBANDRY - MILKING |
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| PILOT
HUSBANDRY |
400
Rabbits Husbandry |
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PRODUCTION FACILITIES :: |
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:::::::: Animal Husbandry
– Milking
BioProtein
Technologies operates a state-of-the-art animal house
currently accommodating up to 400 rabbits at the INRA
site in Magneraud (West France).
These
premises were designed by BioProtein Technologies in
collaboration with INRA in order to meet US and European
regulations.
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More…
The facilities include a confined milking room and a
laboratory dedicated to the genetic analysis of newborn
rabbits. Rabbits are mechanically milked using a milking
machine designed in collaboration with INRA. This allows
the efficient collection of 100
to 150 ml of milk per female per day
of lactating period. |
by
courtesy of Grimaud Frères Selection |
:::::::: Purification
The
purification and analysis of proteins currently
produced by BioProtein in milk is performed by
the customers of the company who generally have
the know-how and infrastructured required.
For
customers who should not have the required capabilities
, BioProtein has developed partnerships with companies
specializing in DSP, protein analysis and bio-safety
testing. |
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A
partnership for large-scale purification
under GMP requirements has been developed
with Eurogentec, a Belgian company specialized and validated
for protein purification in full compliance with GMP
standards. |
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:::::::: Biosafety Testing
& Process Validation
BioProtein Technologies has developed a partnership
with Q-One Biotech Ltd. (Glasgow,
Scotland), an international company with proven expertise
in the area of biosafety testing and process validation,
in accordance with American and European Regulatory
Authorities GLP requirements.
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INVESTORS :: |
| FOUNDERS |
| SGAM
(France)
GILDE (Netherlands)
CREAGRO (France)
IWIC (Luxembourg)
ANVAR
(France) |
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