:::::
COMPANY ::::: |
| 
|
::
MISSION ::
|
| BioProtein
Technologies is a biotechnology company specialized
in the production of recombinant
therapeutic proteins & vaccines in the milk
of transgenic rabbits.
BioProtein
Technologies is a Contract Manufacturing
Organization (CMO). The Company provides pharmaceutical
and biotechnology companies with fully integrated services
from gene expression to industrial production of proteins
and vaccines in milk.
|
| Its
proprietary technology offers customized packages supplying
gram to dozens
kilogram quantities of highly purified biopharmaceuticals
with competitive advantages in terms of scale-up and time
to market.
A strong expertise through the manufacturing process particularly
in molecular and cellular biology, embryology, dairy science,
and animal housing, allows the Company to successfully produce
complex glycosylated proteins
or vaccines
in the milk of transgenic rabbits (e.g. monoclonal
antibodies, plasma proteins, hormones, peptides and VLP-based
multivalent vaccines.) -->
More...
BioProtein
Technologies has demonstrated its ability to meet the most
rigorous specifications in protein production through recombinant
proteins production programs, carried out in collaboration
with several biotechnology companies or pharmaceutical companies.
-->
More
|
|
|
:: HISTORY ::
|
 |
BioProtein
Technologies was founded by three scientists involved in transgenic
animal and cloning research, Louis-Marie Houdebine, Jean-Paul
Renard and Bernard Jégou, and an experienced manager
from the business consultancy world, Marc Le Bozec. They shared
the same view on the potential industrial applications of nearly
20 years of cutting-edge research in the field of gene expression
and transgenic technology.
This view was soon backed by the top management of INRA, which
provided the original core technology. BioProtein Technologies
was thus founded as a spin-off of INRA on July 1st 1998.
|
| Since
its founding, the Company raised a total of € 9.5 M with
private investors and venture capital companies providing the
Company with a solid visibility and stability to implement its
plans. -- > More
|
::::::::::::THE
FOUNDERS
| |
Marc
Le Bozec //graduated from HEC//
He acquired proficiency in business management and in management
of innovation especially within prestigious practices (Bossard
Consultants Gemini Consulting and Arthur D. Little).
Marc Le Bozec acted as CEO of BioProtein for 8 years prior to
take new responsibilities as Chief Financial Officer for Cellectis. |
| |
Louis-Marie
Houdebine //Ph.D, Chemical engineer//
He is director of the Animal Gene Study Laboratory at INRA (French
National Agronomy Research Institute - Jouy-en-Josas, Yvelines
France). He is recognized worldwide as one of the leading
specialists in the production of recombinant proteins in the
milk of transgenic animals. He developed a pole of expertise
in the field of vectors carrying genes. |
| |
Jean-Paul
Renard //Ph.D.,
Engineer in agronomy//
He is director of the Reproduction and Developmental Biology
Unit at INRA (Jouy-en-Josas, Yvelines France). He is
internationally recognized as one of the best specialists in
the field of domestic animal cloning, particularly for pharmaceutical
applications. |
| |
Bernard
Jégou //Ph.D.//
He is director of the Animal Research Group for Male Reproduction
at INSERM (French National Institute for Medical Research -Rennes
University France). He is carrying out ambitious projects
in the field of spermatogenesis. |
| |
François
Deneux //graduated from ESSEC//
He is currently responsible for the healthcare practice
of Arthur D. Little in France.
He has more than 20 years experience in strategy and management
consulting especially within prestigious practices (Bossard
Consultants Gemini Consulting and Arthur D. Little).
He has been Managing Director of BioProtein Technologies from
its creation in July 1998 up to May 2000. |
:::::::::
Back to TOP  |
|
:: COLLABORATIONS ::
|
|
:: INDUSTRIAL PARTNERSHIP :: |
|
| BioProtein
Technologies has concluded manufacturing agreements with LFB (French
Laboratory for Plasma Fractionation and Biotechnology) for feasibility
studies regarding the production of recombinant proteins in the
milk of transgenic rabbits.
|
|
:: RESEARCH PARTNERSHIPS :: |
|
BioProtein
Technologies has a privileged partnership
with INRA (the French National Institute for Agronomic
Research).
INRA is one the most important research institutes in France;
with a budget of € 520 M, 10.000 employees and a number
of patents and breeders rights covering 500 marketed commercial
crops. |
| |
| This
partnership provides BioProtein Technologies with: |
|
| |
Know-how
transfer, particularly in the fields of molecular biology, developmental
biology and animal production. |
| |
Exclusive
access to intellectual property: an exclusive licence for the
production of proteins in milk. |
| |
Logistics
support, laboratory and staff resources. |
BioProtein
Technologies has concluded agreements with top league laboratories
or public research organizations:
| INRA
Laboratory of Cellular and Molecular Biology (LM. Houdebine)
Laboratory of Developmental Biology (JP. Renard)
Laboratory of Gonadotropins Study of (F. Guillou)
Laboratory of Molecular Virology and Immunology (J. Cohen)
INSERM
Laboratory of Lipoprotein Biochemistry (L. Lagrost)
|
|
:::::::::
Back to TOP  |
:: RESOURCES :: |
|
| |
JOUY-EN-JOSAS
SITE (PARIS): RESEARCH & DEVELOPMENT |
| ADMINISTRATION,
OPERATIONS & SALES |
The
team is composed of 3 persons including 1 Chief
Finance Officer, 1 Chief Operating Officer, 1 S&A
secretary |
| MOLECULAR
BIOLOGY |
150
m² Laboratory: Research
and development |
EMBRYOLOGY
|
200
m2 Laboratory: in charge of micro-injection
and embryo transfer experiments. The team is made
up of 2 scientists and 2 technicians. |
| PILOT
HUSBANDRY |
200
Rabbits Husbandry |
|
| 
|
MAGNERAUD
SITE (WEST FRANCE): HUSNBANDRY - MILKING |
| |
|
| PILOT
HUSBANDRY |
400
Rabbits Husbandry. 2 husbandry technicians. |
|
:::::::::
Back to TOP 
| ::
PRODUCTION FACILITIES ::
|
|
:::::::: Animal Husbandry
Milking
BioProtein
Technologies operates a state-of-the-art animal house
currently accommodating up to 400 rabbits at the INRA
site in Magneraud (West France).
These
premises were designed by BioProtein Technologies in
collaboration with INRA in order to meet US and European
regulations. -->
More
The facilities include a confined milking room and a
laboratory dedicated to the genetic analysis of newborn
rabbits. Rabbits are mechanically milked using a milking
machine designed in collaboration with INRA. This allows
the efficient collection of 100
to 150 ml of milk per female per day
of lactating period.
|
by
courtesy of Grimaud Frères Selection |
:::::::: Purification
The
purification and analysis of proteins currently
produced by BioProtein in milk is performed directly
by its customers who generally have the know-how
and infrastructure required.
For
customers who should not have the required capabilities,
BioProtein has developed partnerships with companies
specializing in DSP, protein analysis and bio-safety
testing.
|

|
|
| |
| ::
INVESTORS ::
|
| FOUNDERS |
|
GILDE (Netherlands)
CREAGRO (France)
IWIC (Luxembourg) |
:::::::::
Back to TOP  |
|
|
| |
|